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Peer-reviewed veterinary case report

Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam.

Journal:
Medical mycology
Year:
2011
Authors:
Hummel, James et al.
Affiliation:
Department of Clinical Sciences · United States
Species:
dog

Abstract

Medical therapy for pythiosis is hampered by a lack of efficacious drugs. The present report describes a case of canine gastrointestinal pythiosis in which lesions were resolved through the administration of itraconazole, terbinafine, and the agricultural fungicide mefenoxam. No substantial adverse effects occurred in association with administration of the latter compound. Additional studies are needed to evaluate the pharmacokinetics of mefenoxam and to further assess its tolerability and potential efficacy for the treatment of pythiosis in dogs.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/21174493/