Peer-reviewed veterinary case report
How two dogs recovered from severe manganese poisoning and liver
By Wolf, Jacob et al.·Published in Journal of the American Animal Hospital Association·2023·From the College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Successful Management of Severe Manganese Toxicosis in Two Dogs.
- Species:
- dog
Plain-English summary
Two 5-year-old female Shetland sheepdogs were brought to the vet after accidentally eating a joint supplement that contained manganese, which can be toxic to dogs. Both dogs showed signs of liver injury, and despite initial treatments, their condition worsened. The veterinarians consulted a toxicologist and then treated the dogs with a combination of medications, including calcium EDTA and Vitamin E, which helped restore their liver function to normal. Thankfully, both dogs recovered fully from the manganese poisoning.
People also search for: dog liver injury treatment · Shetland sheepdog manganese poisoning · joint supplement toxicity in dogs
Abstract
Manganese is a common component of human joint supplements and may be a source of ingestion and subsequent toxicosis in dogs. Although hepatotoxicity secondary to manganese toxicosis has been reported in dogs before, no descriptions of successful management of manganese toxicosis has been reported in veterinary literature. A 5 yr old spayed female Shetland sheepdog and a 5 yr old female Shetland sheepdog were evaluated following accidental ingestion of a joint supplement. Consultation with a toxicologist revealed concern for manganese toxicosis resulting in hepatic injury. Both dogs developed subsequent acute liver injury, despite decontamination and initial management with N-acetylcysteine and cholestyramine. The patients were managed with calcium ethylenediaminetetraacetic acid, paraaminosalicylic acid, allopurinol, Vitamin E, ginkgo biloba, and S-adenosylmethionine/silybin. Liver values returned to normal in both dogs. Manganese exposure was confirmed with urine manganese analysis in one dog and fecal examination in the other dog. A previous case report detailed the fatal manganese toxicosis in a dog; this case report describes the successful management of severe acute hepatic injury secondary to manganese toxicosis. The combination of medications used above may be used for successful treatment of manganese toxicosis in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37167249/