Peer-reviewed veterinary case report
How a juvenile diabetic dog's extreme high triglycerides were
By Guarino, Aria L et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2023·Blue Pearl Veterinary Partners, United States·View original on PubMed →
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Original publication title: Successful multimodal treatment of extreme hypertriglyceridemia in a juvenile diabetic dog.
- Species:
- dog
Plain-English summary
A 7-month-old female Pomeranian was brought in with excessive urination, increased thirst, and changes in her eye color. She was diagnosed with severe high triglycerides, diabetes, and eye inflammation. The vet treated her with a combination of medications, including fenofibrate and insulin, along with a low-fat diet and a special procedure to remove excess fat from her blood. Within just two days, her triglyceride levels returned to normal, and all her symptoms disappeared. Six months later, she has not experienced any further issues with high triglycerides while continuing her diabetes treatment.
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Abstract
OBJECTIVE: To describe the therapeutic protocol used to normalize severe hypertriglyceridemia in a dog. CASE SUMMARY: A 7-month-old, 1.2-kg female Pomeranian presented with acute polyuria, polydipsia, and ocular discoloration. Diagnoses included diabetic ketosis, severe hypertriglyceridemia (>225 mmol/L [>20,000 mg/dl]), lipemia retinalis, and bilateral uveitis. The triglyceride concentration was near normal within 2 days of initiating treatment with fenofibrate, regular insulin constant rate infusion (CRI), manual therapeutic plasma exchange (TPE), and a low-fat diet. All clinical signs resolved. The dog has had no relapse of hypertriglyceridemia at the time of writing the manuscript, 6 months later, with continued treatment of diabetes mellitus. NEW OR UNIQUE INFORMATION PROVIDED: This is the first case report documenting the combination of fenofibrate, insulin CRI, and manual TPE for treatment of severe hyperlipidemia in a dog. Detailed protocols for manual TPE and a novel insulin CRI are provided. A discussion of multiple spurious biochemical and hematologic errors associated with the severe hypertriglyceridemia is also provided.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36573353/