Peer-reviewed veterinary case report
Dog with stomach tumor treated successfully with imatinib
By Woo, In-Sun et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2024·Konkuk University Veterinary Medical Teaching Hospital, South Korea·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine triphosphate-based tumor sensitivity assay in a dog.
- Species:
- dog
Plain-English summary
An 11-year-old spayed female Maltese was diagnosed with a gastrointestinal stromal tumor, a rare type of stomach tumor in dogs. After surgery to remove part of the tumor, a special test showed that a medication called imatinib would be effective for her. She was treated with imatinib for 28 months, and there were no signs of the tumor coming back. This case suggests that using specific tests can help vets choose the best chemotherapy after surgery for dogs with these tumors.
People also search for: Maltese dog stomach tumor treatment · imatinib for dog cancer · dog gastrointestinal stromal tumor prognosis
Abstract
Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib. Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor. Key clinical message: Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic drugs for incompletely resected gastrointestinal stromal tumors in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38827592/