Peer-reviewed veterinary case report
Imatinib shrank large inoperable mast cell tumors in two dogs
By J.H. Kim et al.·Published in Veterinární Medicína·2016·Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of Korea, CZ·View original on DOAJ →
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Original publication title: Successful response to imatinib in two dogs with inoperable grade III infiltrating mast cell tumours: a case report
- Species:
- dog
Plain-English summary
Two dogs were brought in because they had rapidly growing lumps on their neck and underarm areas, which were found to be inoperable grade III mast cell tumors (a type of skin cancer). After starting treatment with imatinib, both dogs saw a dramatic reduction in the size of their tumors, with the lumps becoming undetectable within just 10 days. This suggests that imatinib could be an effective treatment option for dogs with these aggressive tumors, even if certain genetic mutations are not present.
People also search for: dog skin cancer treatment · mast cell tumor in dogs · imatinib for dog tumors
Abstract
Two dogs were presented owing to sudden rapid growth of cutaneous masses greater than 10 cm on the neck and axillary region, respectively. Based on history and results of physical examinations, blood work, fine needle aspiration, histopathological examination, and computed tomography, inoperable grade III infiltrating mast cell tumours were diagnosed. After the initiation of imatinib treatment, the masses markedly shrank and became undetectable within 10 days in both dogs, although none of the tumour specimens showed evidence of mutations in sequencing of c-kit exons 8 and 11. These results suggest that imatinib could be a therapeutic option in patients with surgically inoperable canine mast cell tumours, even those that are histopathologically high grade without c-kit exon 8 or 11 mutations.
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Search related cases →Original publication on DOAJ: https://doi.org/10.17221/87/2016-VETMED