Peer-reviewed veterinary case report
How 3 Dogs With Resistant E. coli Colitis Got Better
By Merino-Gutierrez, Virginia et al.·Published in Topics in companion animal medicine·2022·Department of Internal Medicine, Spain·View original on PubMed →
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Original publication title: Successful Treatment of 3 Dogs With Fluoroquinolone-Resistant Escherichia coli Associated Granulomatous Colitis.
- Species:
- dog
Plain-English summary
Three dogs with chronic diarrhea and weight loss were diagnosed with a serious intestinal condition called granulomatous colitis caused by a resistant strain of E. coli. Initially, they were treated with common antibiotics but showed no improvement. However, when a different antibiotic called amikacin was added to their treatment, all three dogs fully recovered and their symptoms resolved. This case highlights the importance of finding effective treatments for antibiotic-resistant infections in dogs.
People also search for: dog chronic diarrhea treatment · E. coli colitis in dogs · amikacin for dog colitis
Abstract
Successful resolution of Escherichia coli associated granulomatous colitis (ECGC) is becoming a challenge due to the development of fluoroquinolone resistant E coli, which is associated with poor prognosis. Three dogs presented with signs of chronic colitis and were diagnosed with ECGC. All 3 were initially treated with enrofloxacin and trimethoprim-sulfamethoxazole, without clinical improvement. Despite the fact that culture and susceptibility testing results demonstrate resistance to fluoroquinolone and trimethoprim-sulfamethoxazole, the addition of amikacin fully resolved the clinical signs in all 3 cases. This case series describes the clinical presentation, diagnostic findings, and successful treatment of 3 dogs with fluoroquinolone-resistant ECGC. It suggests an alternative strategy for multidrug-resistance ECGC patients. Further investigations are required to confirm the efficacy of and to determine the molecular mechanisms underpinning the apparent success of aminoglycoside antibiotic combinations for treatment of ECGC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34965473/