Peer-reviewed veterinary case report
Treatment of two dogs with heart vessel defect and severe lung
By Sugimoto, Keisuke et al.·Published in The Journal of veterinary medical science·2025·Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Successful treatment of patent ductus arteriosus and severe pulmonary hypertension using sildenafil and beraprost sodium in two dogs.
- Species:
- dog
Plain-English summary
Two dogs with a heart condition called patent ductus arteriosus (PDA) and severe pulmonary hypertension (high blood pressure in the lungs) were treated at a veterinary hospital. Initially, they were given sildenafil to help with the pulmonary hypertension, but it didn't show immediate improvement. After surgery to close the duct, they started treatment with beraprost sodium, which led to a significant improvement in their condition. Both dogs recovered well without any signs of heart failure or negative reactions to the medications.
People also search for: dog patent ductus arteriosus treatment · sildenafil for dogs pulmonary hypertension · beraprost sodium for dogs heart condition
Abstract
Two dogs with patent ductus arteriosus and severe pulmonary hypertension were presented to our veterinary teaching hospital. In both dogs, sildenafil was initiated to treat pulmonary hypertension, and surgery was supposed to be scheduled after dose titration. Although no obvious improvement in pulmonary hypertension was observed, no dog had polycythaemia or an increased haematocrit level. The dogs underwent ductal occlusion, and treatment with beraprost sodium was subsequently initiated. Thereafter, severe pulmonary hypertension dramatically improved. No dog showed any clinical sign of right heart failure or adverse drug reaction postoperatively, thereby demonstrating the successful treatment of two dogs with patent ductus arteriosus and severe pulmonary hypertension, using sildenafil and beraprost sodium.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40414725/