Sulforaphane relieved inflammation symptoms in EAP mice by blocking oxidative stress and NLRP3 inflammasome activation through the Nrf2 pathway.

Abstract

Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) are diagnosed in patients with various pelvic or genitourinary symptoms irrespective of the presence of a tender prostate. The etiology of chronic nonbacterial prostatitis remains unclear. Current treatments such as alpha-blockers, neuroleptics, anti-inflammatory, medications, and physical therapy, are often unsatisfactory. New treatments, as well as an improved knowledge of the underlying CP/CPPS pathogenesis, are thus needed. Sulforaphane (SFN), an isothiocyanate found in large quantities in Brassica species, has shown therapeutic effects on inflammation and cancer, and can protect against DNA damage and modulate the cell cycle to control apoptosis, angiogenesis, and metastasis. At the molecular level, SFN modulates cell homeostasis by activating the transcription factor Nrf2. However, its effect on CP/CPPS is not clear. Here, SFN was found to alleviate inflammation by suppressing NLRP3 inflammasomes via the Nrf2/HO-1 axis, as demonstrated in both animal and cellular analyses.