Peer-reviewed veterinary case report
Sulphido-leukotriene levels in normal and atopic dogs with dust mite
By Marsella, R & Nicklin, C F·Published in Veterinary dermatology·2001·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Sulphido-leukotriene production from peripheral leukocytes and skin in clinically normal dogs and house dust mite positive atopic dogs.
- Species:
- dog
Plain-English summary
A group of 13 dogs with skin allergies (atopy) caused by house dust mites were tested to see if their skin and blood produced more sulphido-leukotrienes (s-LT), which are linked to allergic reactions. Surprisingly, the study found no significant difference in s-LT levels between these allergic dogs and 16 healthy dogs. This means that having atopy didn't lead to higher levels of s-LT in their skin or blood. Owners reported the severity of their dogs' allergy symptoms, but there was no connection between those symptoms and the levels of s-LT found in their skin.
People also search for: dog skin allergies treatment · why is my dog itching · house dust mite allergy in dogs · atopic dermatitis in dogs · dog allergy symptoms and management
Abstract
Pathogenesis of canine atopy has not been completely elucidated. In humans, sulphido-leukotrienes (s-LT) play a role in atopy, and increased production of s-LT occurs in the skin and peripheral leukocytes after allergen challenge. The study population included 16 clinically normal and 13 atopic dogs. All atopic dogs had in common a positive reaction (4+) to the intradermal injection of house dust mite (allergen of reference). Blood samples and skin biopsies were collected. Sulphido-LT synthesis by peripheral leukocytes after stimulation was measured, and no statistically significant difference was found between clinically normal and atopic dogs. Sulphido-LT concentrations in skin samples from stimulated and unstimulated sites were measured, and no statistically significant difference was detected between clinically normal and atopic dogs or between lesional and nonlesional skin within the atopic group. Clinical signs of atopic dogs were graded by owners and no correlation was found between their severity and cutaneous concentrations of s-LT. In this study there was no increase in s-LT synthesis in atopic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11301537/