Peer-reviewed veterinary case report
Cyclosporin A stops feline coronavirus from growing in lab tests
By Tanaka, Yoshikazu et al.·Published in Veterinary research·2012·Department of Veterinary Hygiene, Japan·View original on PubMed →
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Original publication title: Suppression of feline coronavirus replication in vitro by cyclosporin A.
- Species:
- cat
Plain-English summary
A laboratory study found that cyclosporin A (CsA), an immunosuppressive medication, can reduce the replication of the feline infectious peritonitis virus (FIPV), which causes a serious and often fatal disease in cats. This research showed that CsA worked effectively in a controlled environment, but more studies are needed to see if it can help cats with FIP in real-life situations. Currently, FIP is considered incurable, so any potential treatments are of great interest to pet owners.
People also search for: cat FIP treatment · feline coronavirus medication · cyclosporin A for cats
Abstract
The feline infectious peritonitis virus (FIPV) is a member of the feline coronavirus family that causes FIP, which is incurable and fatal in cats. Cyclosporin A (CsA), an immunosuppressive agent that targets the nuclear factor pathway of activated T-cells (NF-AT) to bind cellular cyclophilins (CyP), dose-dependently inhibited FIPV replication in vitro. FK506 (an immunosuppressor of the pathway that binds cellular FK506-binding protein (FKBP) but not CyP) did not affect FIPV replication. Neither cell growth nor viability changed in the presence of either CsA or FK506, and these factors did not affect the NF-AT pathway in fcwf-4 cells. Therefore, CsA does not seem to exert inhibitory effects via the NF-AT pathway. In conclusion, CsA inhibited FIPV replication in vitro and further studies are needed to verify the practical value of CsA as an anti-FIPV treatment in vivo.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22546085/