Peer-reviewed veterinary case report
Hyaluronan injections reduce cartilage cell death in dogs with ACL
By Echigo, Ryosuke et al.·Published in The Journal of veterinary medical science·2006·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Suppressive effect of hyaluronan on chondrocyte apoptosis in experimentally induced acute osteoarthritis in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with knee injuries from anterior cruciate ligament tears (ACLT) were treated with hyaluronan, a substance that helps lubricate joints, either through an injection into the joint or through an IV. The dogs that received hyaluronan showed fewer dying cartilage cells compared to those that did not receive treatment. This suggests that hyaluronan can help protect joint health after an ACL injury. Overall, the treatment appeared to be beneficial in reducing cell death in the affected joints.
People also search for: dog knee injury treatment · hyaluronan for dogs · ACL tear in dogs recovery
Abstract
Dogs receiving anterior cruciate ligament transection (ACLT) were treated with either intravenous (IV) or intraarticular (IA) administration of hyaluronan (HA), and differences in appearance of chondrocyte apoptosis of the stifle joint were investigated. Chondrocyte apoptosis was detected using flow cytometry as well as by staining with TdT-mediated dUTP nick end labeling (TUNEL). The percentage of apoptotic chondrocytes in dogs with ACLT was significantly higher than that in intact (non-ACLT) dogs. Dogs treated with IA or IV injection of HA after ACLT had fewer apoptotic chondrocytes than non-treated dogs after ACLT. It was suggested that ACLT-induced apoptosis of chondrocytes was suppressed by HA administration of either IA or IV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16953097/