Peer-reviewed veterinary case report
Serum surfactant protein-A levels in dogs with lung diseases
By Sone, Katsuhito et al.·Published in The Journal of veterinary medical science·2013·Department of Veterinary Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Surfactant protein-A concentration in sera from dogs with pulmonary parenchymal diseases.
- Species:
- dog
Plain-English summary
A group of dogs with breathing problems, including aspiration pneumonia, lung tumors, and blunt traumatic lung injury, had their blood tested for a protein called surfactant protein A (SP-A). The results showed that dogs with these lung issues had higher levels of SP-A compared to healthy dogs, indicating that this protein could help vets identify serious lung diseases. The study suggests that measuring SP-A levels in the blood might be useful for diagnosing lung problems in dogs.
People also search for: dog breathing problems · aspiration pneumonia in dogs · lung tumor treatment for dogs
Abstract
Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmonary parenchymal diseases in dogs. Thirty-two dogs with pulmonary parenchymal diseases, 34 with nonrespiratory diseases and 57 healthy dogs were included. Serum SP-A concentration was measured in all dogs using sandwich enzyme linked immunosorbent assay with an anti-dog SP-A polyclonal antibody. Median serum SP-A concentration in healthy dogs was <2.0 ng/ml, whereas that in dogs with aspiration pneumonia (n=11), primary lung tumors (n=9) and blunt traumatic lung injury (BTLI; n=12) was 3.1, 7.2 and 2.6 ng/ml, respectively; these values were significantly higher than those in healthy dogs. The serum SP-A concentration in dogs with nonrespiratory diseases was comparable with that in healthy dogs. No correlation was observed between the serum SP-A and plasma C-reactive protein concentrations in dogs with aspiration pneumonia and BTLI. There was a significant correlation between the serum SP-A concentration and thoracic radiographic changes in dogs with BTLI. These findings suggest that the serum SP-A concentration may be a useful clinical biomarker of alveolar damage that can be used for differential diagnosis of pulmonary parenchymal diseases and nonrespiratory diseases in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23328605/