Peer-reviewed veterinary case report
Survival and kidney problems after treating hyperthyroid cats
By Williams, T L et al.·Published in Journal of veterinary internal medicine·2010·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Survival and the development of azotemia after treatment of hyperthyroid cats.
- Species:
- cat
Plain-English summary
A group of 300 hyperthyroid cats were monitored to see how their condition affected their kidney health and overall survival. After treatment, about 15% of these cats developed azotemia, which is a buildup of waste in the blood due to kidney issues, within 240 days. The study found that higher levels of certain waste products in the blood were linked to developing azotemia, while factors like urine protein levels and hypertension were associated with shorter survival times. On average, the cats lived about 417 days after diagnosis, and while protein levels didn't directly worsen kidney disease, they were related to overall survival.
People also search for: cat hyperthyroidism treatment · cat kidney disease symptoms · hyperthyroid cat survival rate
Abstract
BACKGROUND: Hyperthyroidism complicates the diagnosis of chronic kidney disease (CKD) as it increases glomerular filtration rate. No practical and reliable means for identifying those cats that will develop azotemia after treatment for hyperthyroidism has been identified. Hyperthyroidism is associated with proteinuria. Proteinuria has been correlated with decreased survival of cats with CKD and with progression of CKD. HYPOTHESIS: Proteinuria and other clinical parameters measured at diagnosis of hyperthyroidism will be associated with the development of azotemia and survival time. ANIMALS: Three hundred client owned hyperthyroid cats treated in first opinion practice. METHODS: Retrospective, cohort study relating clinical parameters in hyperthyroid cats at diagnosis to the development of azotemia within 240 days of diagnosis and survival time (all cause mortality). Multivariable logistic regression analysis was used to identify factors that were predictive of the development of azotemia. Multivariable Cox regression analysis was used to identify factors associated with survival. RESULTS: Three hundred cats were eligible for survival analysis and 216 cats for analysis of factors associated with the development of azotemia. The median survival time was 417 days, and 15.3% (41/268) cats developed azotemia within 240 days of diagnosis of hyperthyroidism. Plasma concentrations of urea and creatinine were positively correlated with the development of azotemia. Plasma globulin concentration was negatively correlated with the development of azotemia. Age, urine protein:creatinine ratio, and the presence of hypertension were significantly correlated with decreased survival time. Urine specific gravity and PCV were significantly correlated with increased survival time. CONCLUSIONS AND CLINICAL IMPORTANCE: The proteinuria associated with hyperthyroidism is not a mediator of progression of CKD; however, it does correlate with all cause mortality.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20649748/