Peer-reviewed veterinary case report
Survival of rats with experimental chronic heart failure depending on pharmacodynamic and pharmacokinetic parameters of angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2006
- Authors:
- Fedorov, V N et al.
- Affiliation:
- Department of Pharmacology
- Species:
- rodent
Abstract
Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity not only prolonged 6-month survival and lifetime, but also decreased the mortality rate of rats with decompensation of chronic heart failure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16929960/