Peer-reviewed veterinary case report
Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model.
- Journal:
- Kidney international
- Year:
- 2010
- Authors:
- Brosius, Frank C
- Affiliation:
- Department of Internal Medicine · United States
- Species:
- rodent
Abstract
Diabetic nephropathy is a common, complex disease with a clear genetic predisposition. Human gene association studies are beginning to bear fruit by identifying gene loci that increase diabetic nephropathy risk. Chua et al. report a similar study in diabetic mice that reveals a major nephropathy locus on chromosome 8. Could this be a human nephropathy gene? Time will tell, but such findings will at least improve the use of mouse models of human kidney disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20706214/