Peer-reviewed veterinary case report
Dog had severe allergic shock after tranexamic acid injection
By Choi, Jin-Young et al.·Published in The Journal of veterinary medical science·2019·>Department of Veterinary Emergency Medicine, South Korea·View original on PubMed →
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Original publication title: Suspected anaphylactic shock associated with administration of tranexamic acid in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old male Maltese was brought in with blood in his urine and difficulty urinating after surgery to remove bladder stones. He was diagnosed with sterile hemorrhagic cystitis and underwent treatment, but the next day he experienced severe bleeding and anemia. To help stop the bleeding, he was given tranexamic acid, but this caused an unexpected allergic reaction known as anaphylactic shock, leading to low blood pressure and other serious symptoms. Fortunately, emergency treatment with fluids, steroids, and antihistamines quickly stabilized him, and he recovered within minutes.
People also search for: dog blood in urine treatment · Maltese allergic reaction · tranexamic acid side effects in dogs
Abstract
A 10-year-old male castrated Maltese was referred with clinical signs of hematuria, stranguria, and pollakiuria. The dog was diagnosed with sterile hemorrhagic cystitis with urethroliths and cystoliths. To remove the uroliths, the dog underwent retrograde urohydropropulsion followed by a cystotomy. The following day, persistent bleeding in the urinary bladder was identified with large hematoma, hematuria and anemia. In order to reduce bleeding, the dog received 10 mg/kg of tranexamic acid (TXA) intravenously. Immediately after TXA administration, the dog developed anaphylactic shock manifested by hypotension, hypothermia, tachycardia and a dull mentation. Thus, an emergency treatment including bolus injection of crystalloid, administration of dexamethasone and diphenhydramine, and oxygen supplementation was given, after which the dog quickly recovered within a few minutes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31406035/