Peer-reviewed veterinary case report
Skin injuries in seven dogs after carboplatin chemotherapy leaks
By Miller, Kristina Bowles et al.·Published in Journal of the American Animal Hospital Association·2018·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Suspected Carboplatin Extravasation Reactions in Seven Dogs.
- Species:
- dog
Plain-English summary
Seven dogs developed skin injuries after receiving a chemotherapy drug called carboplatin, which can cause irritation if it leaks out of the vein during administration. These injuries appeared about a week after treatment and resembled serious skin damage. The wounds were treated with various methods, including medical care and surgery, and typically healed within about 25 days. There were no clear reasons why these reactions happened in these dogs, but it's important for pet owners to be aware that such complications can occur with carboplatin chemotherapy.
People also search for: dog chemotherapy side effects · carboplatin extravasation treatment · skin injury after dog cancer treatment
Abstract
Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors' knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature. In this case series, seven dogs are described to have experienced injuries following a suspected carboplatin extravasation resembling vesicant injuries a median of 7 days after carboplatin administration (range 4-15 days). Wounds healed with a variety of treatments, including medical management and/or surgical debridement, a median of 25.5 days (range 7-49 days) after observation of the suspected extravasation injury. There were no obvious similarities involving carboplatin administration among patients to explain why these reactions occurred. Extravasation injury should be considered a possible local complication associated with carboplatin chemotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30272477/