Peer-reviewed veterinary case report
Chinese Shar Pei puppies with pneumonia linked to ciliary problems
By Dhein, C R et al.Ā·Published in American journal of veterinary researchĀ·1990Ā·Department of Veterinary Clinical Medicine and Surgery, United StatesĀ·View original on PubMed ā
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Original publication title: Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia.
- Species:
- dog
Plain-English summary
A group of young Chinese Shar Pei puppies developed chronic pneumonia, affecting four out of six in the litter. Unfortunately, two of the puppies died due to severe pneumonia and other health issues. Tests showed that their respiratory cilia, which help clear mucus and debris from the lungs, were not functioning properly, likely contributing to their pneumonia. While some immune system tests were normal, the puppies' ciliary dysfunction made it harder for them to clear mucus, leading to respiratory problems.
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Abstract
Chronic pneumonia was investigated in a litter of young Chinese Shar Pei in which 4 of 6 dogs were affected. Serum immunoglobulin concentrations (IgA, IgG, IgM) determined by radial immunodiffusion varied over time, but were not consistently lower in affected dogs, compared with control dogs. Two dogs that died had hydrocephalus and lymphoid depletion, in addition to severe broncho-pneumonia. Evaluation of ciliary ultrastructure in 2 affected dogs revealed random orientation of adjacent respiratory tract or oviductal cilia and a greater number of microtubular disarrangements, compared with control dogs. In vivo tracheal mucociliary clearance of 99mtechnetium macroaggregated albumin was absent in 1 dog examined. The ciliary abnormalities were suspected to have resulted in an inefficient mucociliary transport system predisposing to the development of pneumonia. Further evaluation of 1 Chinese Shar Pei revealed lymphocyte mitogenesis results that were not consistently less than those of a control dog, normal total hemolytic complement values, and normal blood neutrophil chemotaxis.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2316922/