Peer-reviewed veterinary case report
Vomiting and liver enzyme rise in dogs treated with doxycycline
By Schulz, B S et al.·Published in The Veterinary record·2011·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Suspected side effects of doxycycline use in dogs - a retrospective study of 386 cases.
- Species:
- dog
Plain-English summary
A group of dogs treated with doxycycline for infections experienced side effects, including vomiting in about 18% of cases and diarrhea in 7%. Older dogs were more likely to show these symptoms, and some had increased liver enzyme levels, which can indicate liver stress. The risk of liver enzyme increases was linked to the dose of doxycycline given. If your dog is on doxycycline and shows signs of vomiting or diarrhea, it's important to talk to your veterinarian about adjusting the treatment or monitoring liver health.
People also search for: dog vomiting after doxycycline · doxycycline side effects in dogs · dog diarrhea treatment · liver enzyme increase in dogs · doxycycline dosage for dogs
Abstract
This study investigated doxycycline-related side effects in a large population of dogs. Data from 386 dogs that had received doxycycline for the treatment of various infectious diseases were analysed retrospectively. Potential side effects that developed during treatment were documented, and correlations with signalment, dose, duration of treatment, frequency of application, doxycycline preparation and use of additional drugs were investigated. Vomiting was reported in 18.3 per cent of dogs, 7.0 per cent developed diarrhoea and 2.5 per cent developed anorexia. While being treated with doxycycline, 39.4 per cent of dogs showed an increase in alanine aminotransferase (ALT) activity and 36.4 per cent showed an increase in alkaline phosphatase (ALP) activity. There was a dose-related risk of an increase in ALP activity (P=0.011, odds ratio [OR]=1.27, 95 per cent confidence interval [CI] 1.06 to 1.53), and older dogs treated with doxycycline were more likely to develop an increase in ALT activity (P=0.038, OR=1.23, 95 per cent CI 1.01 to 1.50) and vomiting (P=0.017, OR=1.11, 95 per cent CI 1.02 to 1.21).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21791480/