Peer-reviewed veterinary case report
Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2014
- Authors:
- Tourteau, Aurélien et al.
- Affiliation:
- Université · France
- Species:
- rodent
Abstract
A series of 3-carboxamido-5-aryl-isoxazoles designed as CB2 agonists were evaluated as FAAH inhibitors. The pharmacological results led to identify structure-activity relationships enabling to switch cannabinoid response from CB2 agonists to FAAH inhibitors. Two compounds were selected for their FAAH and/or CB2 activity, and evaluated in a colitis model for their anti-inflammatory activity. Results showed that compounds 10 and 11 inhibit the development of DSS-induced acute colitis in mice and then, are interesting leads to explore new drug candidates for IBD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24508127/