Peer-reviewed veterinary case report
Syndecan-1 and E-Cadherin in Dog Skin Squamous Cell Cancer
By Rita Files et al.·Published in Veterinary Sciences·2024·Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal, CH·View original on DOAJ →
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Original publication title: Syndecan-1 and E-Cadherin Expression in Canine Cutaneous Squamous Cell Carcinoma
- Species:
- dog
Plain-English summary
A study looked at skin tumors called cutaneous squamous cell carcinoma (CSCC) in dogs, which often develop in areas with less pigmentation due to sun exposure. Researchers examined the levels of two proteins, syndecan-1 and E-cadherin, to see how they relate to the severity of these tumors. They found that lower levels of syndecan-1 and E-cadherin were linked to more aggressive tumors. This suggests that these proteins could be important for understanding how serious a dog's skin cancer might be. More research is needed to confirm these findings and their implications for treatment.
People also search for: dog skin cancer symptoms · canine squamous cell carcinoma treatment · what to do for dog skin tumors
Abstract
Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure. Identifying new biomarkers, such as syndecan-1 (CD138) and E-cadherin, is fundamental for tumor diagnosis and prognosis. Dysregulation of syndecan-1, expressed in epithelial tissue, fibroblasts, and plasma cells, is associated with poor prognosis in several types of cancer. Similarly, E-cadherin, which plays a crucial role in cell adhesion and epithelial functionality, is also linked to adverse outcomes. This study evaluated the expression of syndecan-1 and E-cadherin in 47 cases of canine cutaneous squamous cell carcinoma. The results showed that the intensity of syndecan-1 decreased with increasing tumor aggressiveness, and its presence in the stroma was significantly associated with tumor grade. E-cadherin also demonstrated a decrease in intensity with increasing malignancy. However, the association between syndecan-1 and E-cadherin was not statistically significant. E-cadherin reduction and stromal syndecan-1 positivity seem to be associated with tumor aggressiveness in canine cutaneous squamous cell carcinoma. Further studies are needed to explore their roles in tumor progression.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/vetsci11120652