Peer-reviewed veterinary case report
Dog with liver disease and low sodium from SIADH syndrome
By Kang, Min-Hee & Park, Hee-Myung·Published in The Journal of veterinary medical science·2012·BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases and Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Syndrome of inappropriate antidiuretic hormone secretion concurrent with liver disease in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old female Chihuahua collapsed suddenly and was taken to the vet, where tests revealed high liver enzyme levels. Initial treatment with antibiotics for a liver infection didn’t help, and her condition worsened with low sodium levels. After further testing, she was diagnosed with syndrome of inappropriate antidiuretic hormone secretion (SIADH), likely linked to an immune-related liver issue. Treatment with immunosuppressive medication and limiting her water intake successfully improved her symptoms and resolved the SIADH.
People also search for: Chihuahua collapse · dog liver disease treatment · SIADH in dogs · immune-mediated liver disease in dogs · dog low sodium levels treatment
Abstract
A 5-year-old female Chihuahua was presented for acute collapse. Laboratory examinations showed markedly elevated levels of hepatobiliary enzymes. Empiric antibiotic therapy for bacterial infection of the liver was ineffective. The clinical signs worsened with the development of hyponatremia with hypoosmolality and elevated urine sodium levels. The dog was suspected of having acute cholangiohepatitis associated with an immune-mediated disease. Subsequently, it was diagnosed with syndrome of inappropriate antidiuretic hormone secretion (SIADH) on the basis of the specific disease criteria. Further tests showed normal function of the adrenal and thyroid glands, and MRI and cerebrospinal fluid (CSF) analysis did not show any intracranial diseases. Immunosuppressive therapy and water restriction resolved the clinical signs and improved the SIADH in this dog. This case indicates that SIADH can occur concurrently with suspected immune-mediated liver disease in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22185769/