Peer-reviewed veterinary case report
Natural eugenol and silver nanoparticles fight dog eye infection
By Cabral, Weslei Roberto Correia et al.·Published in Molecules (Basel, Switzerland)·2025·Laborató, Brazil·View original on PubMed →
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Original publication title: Synergistic Antibacterial Effect of Eugenol and Biogenic Silver Nanoparticles onIsolated from Canine Keratoconjunctivitis Sicca.
- Species:
- dog
Plain-English summary
A study found that a natural compound called eugenol, combined with silver nanoparticles, can effectively fight bacterial infections in dogs, particularly those caused by a common opportunistic pathogen. This combination showed strong antibacterial effects, especially against bacteria that form biofilms, which are harder to treat. Importantly, the treatments were found to be less toxic to healthy cells, making them a safer option. These findings suggest that using eugenol and silver nanoparticles together could be a promising new way to help manage bacterial infections in dogs.
People also search for: dog eye infection treatment · natural remedies for dog keratoconjunctivitis · eugenol for dogs · silver nanoparticles for dog infections
Abstract
Plants are a valuable source of bioactive compounds with therapeutic potential. Antibacterials of natural origin represent a promising and sustainable alternative in the fight against bacterial infections. In addition to being effective against bacterial growth, these natural agents may have lower toxicity and fewer side effects, which reinforces their value in the development of new therapeutic strategies. This study reports on the antibacterial effect of eugenol (EUG) and biogenic silver nanoparticles (bioAgNPs) synthesized using the aqueous extract ofA. Juss. bark, alone or in combination, against planktonic and sessile cells of multidrug-resistant, one of the main opportunistic pathogens in dogs. EUG and bioAgNPs showed a dose- and time-dependent bactericidal effect on planktonic cells, interfering with cell membrane integrity. The interaction between EUG and bioAgNPs was classified as synergistic or indifferent for planktonic cells. Except for one isolate, the combination exhibited a synergistic effect for biofilms previously formed on abiotic surfaces for 24 h. Both bioactive compounds promoted morphological and ultrastructural changes inbiofilms. All concentrations of EUG and bioAgNPs in synergistic or indifferent combinations showed reduced toxicity to mammalian cells. These findings suggest that the EUG and bioAgNP combination could be a promising strategy for controllinginfections.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40871505/