Peer-reviewed veterinary case report
Matrix metalloproteinase activity in synovial fluid of dogs
By Murakami, Kohei et al.·Published in The Journal of veterinary medical science·2016·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders.
- Species:
- dog
Plain-English summary
A group of dogs with joint problems, including idiopathic polyarthritis and cranial cruciate ligament rupture, had their joint fluid tested for specific enzymes that can indicate inflammation. The results showed that dogs with cranial cruciate ligament rupture had higher levels of one enzyme (MMP-2) compared to healthy dogs, while those with idiopathic polyarthritis had increased levels of another enzyme (MMP-9). These findings suggest that different joint disorders may cause varying levels of these enzymes, which could help veterinarians understand the underlying issues better.
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Abstract
The activity of matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fluids (SF) sampled from dogs with joint disorders was investigated by gelatin zymography and densitometry. Pro-MMP-2 showed similar activity levels in dogs with idiopathic polyarthritis (IPA; n=17) or canine rheumatoid arthritis (cRA; n=4), and healthy controls (n=10). However, dogs with cranial cruciate ligament rupture (CCLR; n=5) presented significantly higher pro-MMP-2 activity than IPA and healthy dogs. Meanwhile, dogs with IPA exhibited significantly higher activity of pro- and active MMP-9 than other groups. Activity levels in pro- and active MMP-9 in cRA and CCLR dogs were not significantly different from those in healthy controls. Different patterns of MMP-2 and MMP-9 activity may reflect the differences in the underlying pathological processes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26902805/