Peer-reviewed veterinary case report
Synovial fluid protein levels help diagnose canine idiopathic
By Murakami, Kohei et al.·Published in The Journal of veterinary medical science·2016·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Synovial fluid total protein concentration as a possible marker for canine idiopathic polyarthritis.
- Species:
- dog
Plain-English summary
A group of dogs with idiopathic polyarthritis (a type of joint inflammation) had their joint fluid tested to see if total protein levels could help diagnose the condition, even if the dogs were on glucocorticoid medication. The study found that the protein levels in the joint fluid of these dogs were significantly higher than in dogs without arthritis or healthy dogs. This means that measuring total protein in the joint fluid can be a reliable way to diagnose idiopathic polyarthritis, even when the dog is receiving treatment.
People also search for: dog joint inflammation diagnosis · glucocorticoid therapy for dog arthritis · idiopathic polyarthritis in dogs
Abstract
Idiopathic polyarthritis (IPA) is a very common inflammatory arthropathy in the dog. Canine IPA is diagnosed mainly by detecting increased number of leukocytes in the synovial fluid (SF), which is easily influenced by glucocorticoid therapy. We obtained 31 SF samples from 24 IPA dogs prior to (n=19) and/or after (n=12) 1 to 10 weeks of glucocorticoid therapy. The SF total protein concentrations of IPA dogs were significantly higher than those of dogs with non-arthritis diseases (n=34) and healthy controls (n=10). Our data revealed that the SF total protein concentrations are not influenced by several weeks of glucocorticoid therapy. Hence, the SF total protein concentration is applicable as a diagnostic marker of canine IPA even when the patients are receiving glucocorticoid therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26234738/