Peer-reviewed veterinary case report
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
- Journal:
- European journal of medicinal chemistry
- Year:
- 2007
- Authors:
- Gonzalez, Jose L et al.
- Affiliation:
- Department of Chemistry and Center for Biotechnology and Drug Design · United States
Abstract
A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei rhodesiense (T. b. r.), Plasmodium falciparum (P. f.), Leshmania donovani (L. d.) and Trypanasoma cruzi (T. c.), and in vivo against T. b. r. Certain compounds show promising in vitro activity against T. b. r. and P. f. and have superior in vivo activity against T. b. r. to that of pentamidine and furamidine.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17178177/