Peer-reviewed veterinary case report
Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities.
- Journal:
- Bioorganic & medicinal chemistry
- Year:
- 2015
- Authors:
- Wang, Wenbin et al.
- Affiliation:
- China Pharmaceutical University · China
- Species:
- rodent
Abstract
A series of isoflavone amides were designed with isoflavone in place of the scaffold of 2-arylbenzoxazole as cholesterol ester transfer protein (CETP) inhibitors. Twelve new compounds were synthesized, and their inhibitory activities of CETP and preadipocyte proliferation were assayed. The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster. The results indicate that HY-2c exhibited favorable antihyperlipidemic and preadipocyte antiproliferative activities.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26145818/