Peer-reviewed veterinary case report
Synthesis and biological evaluation of technetium-99m labeled galactose derivatives as potential asialoglycoprotein receptor probes in a hepatic fibrosis mouse model.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2013
- Authors:
- Chang, Wen-Yi et al.
- Affiliation:
- Department of Biomedical Imaging and Radiological Sciences
- Species:
- rodent
Abstract
Two galactose derivatives, a monovalent (99m)Tc-MAMA-MGal galactoside and a divalent (99m)Tc-MAMA-DGal galactoside, were synthesized and radiolabeled in high radiochemical purity (>98%). Dynamic microSPECT imaging and biodistribution study of two traces in normal and liver fibrosis mice showed that the (99m)Tc-MAMA-DGal revealed higher specific binding to asialoglycoprotein receptors in liver and then rapidly excreted via both hepatobiliary system and renal clearance. The results suggest that (99m)Tc-MAMA-DGal may be used as SPECT probes for noninvasive evaluation of asialoglycoprotein receptor-related liver dysfunction.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24119556/