Peer-reviewed veterinary case report
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
- Journal:
- Bioorganic & medicinal chemistry
- Year:
- 2011
- Authors:
- Shao, Liming et al.
- Affiliation:
- Discovery and Early Clinical Research · United States
Abstract
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activity. The detailed synthesis and in vitro activity and ADME profile of compounds is described, which represent a previously undisclosed triple reuptake inhibitor chemotype.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21093273/