Peer-reviewed veterinary case report
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2009
- Authors:
- Williams, Richard et al.
- Affiliation:
- Department of Pharmacology · United States
Abstract
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19640716/