Peer-reviewed veterinary case report
Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2011
- Authors:
- Su, Jing et al.
- Affiliation:
- Merck Research Laboratory · United States
Abstract
SAR exploration at C-6 and C-8 positions of the tricyclic sulfone series was carried out. Several functional groups were found to be well tolerated at C-6 and C-8 positions. Selective combination of C-6 and C-8 modification resulted in new tricyclic sulfone analogs with efficacy in in vivo mouse Aβ(40) lowering model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21515050/