Peer-reviewed veterinary case report
Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity.
- Journal:
- Molecules (Basel, Switzerland)
- Year:
- 2018
- Authors:
- Lu, Nan et al.
- Affiliation:
- School of Pharmaceutical Engineering · China
- Species:
- rodent
Abstract
The thienopyridines class of drugs used as P2Yreceptor antagonists plays a vital role in antiplatelet therapy. To further optimized this compound class, we designed and synthesized a series of amino acid prodrugs of 2-hydroxytetrahydrothienopyridine. All compounds were then evaluated for their inhibitory effect on ADP-induced platelet aggregation in rats and then EDand bleeding time of the most potent compounds were compared with commercial drugs. The results showed compoundcould be a potent and safe candidate for further research.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29710801/