Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

Abstract

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. We observed arterial pressure increase, a decrease of alive fetus toward the end of pregnancy and insulin resistance increase in pregnant L-NAME mice and no much difference was detected in pregnant L-NAME-RGO mice. We also observed an arterial pressure increase in normal L-NAME mice. In this paper, we determined a protective impact of RGO in investigational pre-eclampsia.