Peer-reviewed veterinary case report
Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2019
- Authors:
- Huo, Chang-Xin et al.
- Affiliation:
- Institute for Quantitative Health Science & Engineering · United States
- Species:
- rodent
Abstract
The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30924468/