Peer-reviewed veterinary case report
How amitriptyline and buspirone enter cats' blood after oral or skin
By Mealey, K L et al.·Published in Journal of veterinary internal medicine·2004·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats.
- Species:
- cat
Plain-English summary
A group of 6 healthy adult cats was tested to see how well they absorbed two medications, amitriptyline and buspirone, when given either by mouth or through the skin. The results showed that the cats absorbed much less of the medications when applied to the skin compared to taking them orally. Because of this, veterinarians and cat owners should be cautious about using the skin application method for these treatments until more information is available.
People also search for: cat anxiety medication · amitriptyline for cats · buspirone for cats · cat medication absorption · transdermal medication for cats
Abstract
A prospective study was performed to determine the relative availability of buspirone and amitriptyline after oral and transdermal routes of administration in 6 adult cats. For topical administration, drugs were compounded in a transdermal organogel containing pluronic and lecithin (PLO). Using a crossover design, each cat received a single dose of amitriptyline (5 mg) and buspirone (2.5 mg) by the transdermal and oral route of administration with at least a 2-week washout interval between drug treatments. Blood samples were obtained at 0, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after drug administration for determination of plasma drug concentrations. Plasma concentrations of immunoreactive amitriptyline and buspirone were determined using commercial enzyme-linked immunosorbent assay (ELISA) tests. Systemic absorption of amitriptyline and buspirone administered by the transdermal route was poor compared with the oral route of administration. Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14765730/