Peer-reviewed veterinary case report
Dog with high blood pressure and eye damage after PPA overdose
By Ginn, Jennifer A et al.·Published in Journal of the American Animal Hospital Association·2013·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old spayed female Labrador retriever was brought to the vet after accidentally taking too much phenylpropanolamine (PPA), a medication that can cause serious side effects. She showed signs of anxiety, heart problems, and eye issues, including bleeding in the eye. The vet found that her blood pressure was dangerously high and treated her with medications to stabilize her heart and lower her blood pressure. Fortunately, all her health issues improved within a week, and her eye problems cleared up in about a month.
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Abstract
A 4 yr old spayed female Labrador retriever was examined 4 hr after ingesting an overdose of phenylpropanolamine (PPA). Clinical signs included anxiety, piloerection, mucosal ulceration, cardiac arrhythmia, mydriasis, and hyphema. Clinicopathologic abnormalities included elevated creatine kinase (CK) and aspartate aminotransferase (AST), proteinuria, and pigmenturia. Ventricular tachycardia and severe systemic hypertension were documented. Hyphema and retinal detachment were documented oculus uterque (OU). Phenoxybenzamine, sotalol, and esmolol resolved the ventricular tachycardia, and blood pressure was controlled with nitroprusside. All clinicopathologic and cardiac abnormalities resolved within 7 days, and ocular changes resolved within 1 mo. Monitoring of blood pressure and rapid pharmacologic intervention were successful in controlling hypertension secondary to PPA overdose and minimizing retinal damage.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23148140/