Peer-reviewed veterinary case report
T cell fate and clonality inference from single-cell transcriptomes.
- Journal:
- Nature methods
- Year:
- 2016
- Authors:
- Stubbington, Michael J T et al.
- Affiliation:
- European Bioinformatics Institute (EMBL-EBI) · United Kingdom
Abstract
We developed TraCeR, a computational method to reconstruct full-length, paired T cell receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links T cell specificity with functional response by revealing clonal relationships between cells alongside their transcriptional profiles. We found that T cell clonotypes in a mouse Salmonella infection model span early activated CD4(+) T cells as well as mature effector and memory cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26950746/