Peer-reviewed veterinary case report
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
- Journal:
- Nature neuroscience
- Year:
- 2024
- Authors:
- Kedia, Shreeya et al.
- Affiliation:
- Institute of Neuronal Cell Biology · Germany
Abstract
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38937583/