Peer-reviewed veterinary case report
Takes one to B1a: Dismantling the origin of mantle cell lymphoma.
- Journal:
- The Journal of experimental medicine
- Year:
- 2021
- Authors:
- Beaudin, Anna E
Abstract
Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34529750/