Peer-reviewed veterinary case report
Taking the STING Out of Sepsis?
- Journal:
- Cell host & microbe
- Year:
- 2020
- Authors:
- Vandewalle, Jolien et al.
- Affiliation:
- Department of Biomedical Molecular Biology
- Species:
- rodent
Abstract
In this issue of Cell Host & Microbe, Zhang et al. use a sepsis mouse model to show that macrophage-specific release of coagulation factor F3 depends on pathogen detection and responses mediated by TMEM173/STING. The therapeutic power of targeting TMEM173/STING-F3 is evident in mice, but will it penetrate the sepsis bedside?
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32272071/