Peer-reviewed veterinary case report
Tandem hydrothiocyanation/cyclization of CF<sub>3</sub>-iminopropargyl alcohols with NaSCN in the presence of AcOH.
- Year:
- 2025
- Authors:
- Shulgin RS et al.
- Affiliation:
- A.E. Favorsky Irkutsk Institute of Chemistry
Abstract
The synthesis of trifluoromethylated isothiazolium thiocyanates and 4-thiocyanato-2,5-dihydrofurans is presented through hydrothiocyanation/cyclization of CF<sub>3</sub>-iminopropargyl alcohols using NaSCN in AcOH/MeCN. The formation of the two products can be explained by different directions of cyclization of the primary adducts of thiocyanic acid at the triple bond - vinyl thiocyanates. This protocol features simple operating, readily prepared starting materials and occurs under relatively mild conditions.
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Search related cases →Original publication: https://europepmc.org/article/MED/41438336