Peer-reviewed veterinary case report
(-)-Tarchonanthuslactone exerts a blood glucose-increasing effect in experimental type 2 diabetes mellitus.
- Journal:
- Molecules (Basel, Switzerland)
- Year:
- 2015
- Authors:
- de Souza, Gabriela F P et al.
- Affiliation:
- University of Campinas · Brazil
- Species:
- rodent
Abstract
A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25808148/