Peer-reviewed veterinary case report
Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.
- Journal:
- Cell reports. Medicine
- Year:
- 2025
- Authors:
- Negatu, Seble G & Jurado, Kellie A
- Affiliation:
- Department of Microbiology · United States
Abstract
Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al.demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40107239/