Peer-reviewed veterinary case report
Targeting ROCK2 for Atopic Dermatitis Relief.
- Journal:
- Journal of medicinal chemistry
- Year:
- 2026
- Authors:
- Liu, Weilong & Ju, Jianhua
- Affiliation:
- School of Pharmaceutical Sciences · China
Abstract
Atopic dermatitis (AD) remains a significant therapeutic challenge. This Viewpoint summarizes the discovery of compound, a natural product-inspired selective ROCK2 inhibitor, whose design was guided by the identification of a novel hydrophobic surface unique to ROCK2. The compound demonstrates compelling efficacy in a mouse model of MC903-induced AD, positioning selective ROCK2 inhibition as a promising strategy for this condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41758923/