Peer-reviewed veterinary case report
Targeting TIM-3 to halt lung precancer progression.
- Journal:
- Trends in cancer
- Year:
- 2025
- Authors:
- Papavassiliou, Kostas A et al.
- Affiliation:
- First University Department of Respiratory Medicine
- Species:
- rodent
Abstract
Little is known about lung precancer progression. Recently, Zhu et al. explored the early immunologic landscape of lung adenocarcinoma (LUAD) precursors and identified T cell immunoglobulin and mucin domain 3 (TIM-3) as a putative immune checkpoint target for precancer interception. TIM-3 blockade in mice harboring premalignant lesions delayed progression to invasive adenocarcinoma, suggesting potential clinical utility in high-risk individuals detected through screening.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40675881/