Peer-reviewed veterinary case report
Telithromycin inhibits the number of viable bacteria but not lymphocyte accumulation in a murine model of chronic respiratory infection.
- Journal:
- Chemotherapy
- Year:
- 2007
- Authors:
- Yanagihara, Katsunori et al.
- Affiliation:
- Second Department of Internal Medicine · Japan
Abstract
The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17192707/