Peer-reviewed veterinary case report
Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2009
- Authors:
- Woolhiser, Lisa K et al.
- Affiliation:
- Department of Microbiology · United States
- Species:
- rodent
Abstract
This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18852269/