Peer-reviewed veterinary case report
Tetherin upregulation in simian immunodeficiency virus-infected macaques.
- Journal:
- Journal of virology
- Year:
- 2013
- Authors:
- Rahmberg, Andrew R et al.
- Affiliation:
- Department of Microbiology and Immunobiology · United States
Abstract
Here we show that simian immunodeficiency virus (SIV) infection of rhesus macaques results in rapid upregulation of tetherin (BST-2 or CD317) on peripheral blood lymphocytes, including the CD4(+) CCR5(+) T cell targets of virus infection, with a peak of induction that coincides with peak alpha interferon (IFN-α) levels in plasma, and that tetherin remains above baseline levels throughout chronic infection. These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24109219/