Peer-reviewed veterinary case report
TGF-β Inhibition and Immunotherapy: Checkmate.
- Journal:
- Immunity
- Year:
- 2018
- Authors:
- Ganesh, Karuna & Massagué, Joan
- Affiliation:
- Sloan Kettering Institute · United States
Abstract
Immune checkpoint therapy can induce durable remissions, but many tumors demonstrate resistance. In a recent issue of Nature, Mariathasan et al. (2018) and Tauriello et al. (2018) identify stromal TGF-β signaling as a determinant of immune exclusion. Combination TGF-β inhibition and immunotherapy induces complete responses in mouse models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29669246/