Peer-reviewed veterinary case report
The accuracy of intraoperative cytopathological diagnosis compared with conventional histopathological diagnosis.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2000
- Authors:
- Eich, C S et al.
- Affiliation:
- Department of Surgery · United States
Plain-English summary
Researchers looked at how accurate a quick test done during surgery (intraoperative cytopathological diagnosis) is compared to a more detailed test done later (conventional histopathological diagnosis). They examined samples from 65 dogs, 30 cats, and five exotic animals, finding that they could make a specific diagnosis in 42% of cases and correctly identify the type of disease in 41%. Overall, the quick test was accurate 83% of the time, and this improved to 90% when they didn't include samples from the spleen. For diagnosing tumors (neoplasia), the accuracy was 87%, with a very high rate of correctly identifying true positives and no false positives. This means that the quick test is a reliable way to identify tumors during surgery.
Abstract
To determine the accuracy of intraoperative cytopathological diagnosis compared with conventional histopathological diagnosis, the authors obtained 100 specimens from masses of various organ systems chosen randomly from 65 dogs, 30 cats, and five exotic animals. Of the 100 specimens, a specific diagnosis was obtained in 42%, the correct pathological process (i.e., mesenchymal neoplasia, epithelial neoplasia, round cell neoplasia, or inflammation) was identified in 41%, in 1% the diagnosis was deferred, and in 16% an incorrect diagnosis was obtained. The overall accuracy rate of intraoperative cytopathological examination was 83%, which increased to 90% by the exclusion of splenic masses. The accuracy rate of diagnosing neoplasia was 87%, with a sensitivity of 89% and a specificity of 100%. Intraoperative cytopathological examination is an accurate diagnostic method with good sensitivity and specificity for the identification of neoplasia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/10667401/